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Theory Refinement on Bayesian Networks Proc 7th Conf on Uncertainty in Artificial Intelligence (UAI 91, Los Angeles, CA, USA), 52 60 Morgan Kaufmann, San Mateo, CA, USA 1991 [Buntine 1994] W Buntine Operations for Learning with Graphical Models Journal of Artificial Intelligence Research 2:159 225 Morgan Kaufmann, San Mateo, CA, USA 1994 [de Campos 1996] LM de Campos Independence Relationships and Learning Algorithms for Singly Connected Networks DECSAI Technical Report 96-02-04, Universidad de Granada, Spain 1996 [de Campos et al 1995] LM de Campos, J Gebhardt, and R Kruse Axiomatic Treatment of Possibilistic Independence In: [Froidevaux and Kohlas 1995], 77 88 [de Campos et al 2000] LM de Campos, JF Huete, and S Moral Independence in Uncertainty Theories and Its Application to Learning Belief Networks In: [Gabbay and Kruse 2000], 391 434 [Carnap 1958] R Carnap Introduction to Symbolic Logic and Its Applications.

Dover, New York, NY, USA 1958 [Castillo et al 1997] E Castillo, JM Gutierrez, and AS Hadi Expert Systems and Probabilistic Network Models Springer-Verlag, New York, NY, USA 1997 [Castillo 2008] G Castillo Adaptive Learning Algorithms for Bayesian Network Classifiers AI Communications 21(1):2008 IOS Press, Amsterdam, Netherlands 2008 [Chapman et al 1999] P Chapman, J Clinton, T Khabaza, T Reinartz, and R Wirth The CRISP-DM Process Model NCR, Denmark 1999 http://wwwncrdk/CRISP/..

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Endometrial hyperplasia is a result of estrogen excess in the absence of adequate progesterone.2, 4, 5 Often this estrogen excess is due to obesity, polycystic ovarian disease, or prolonged anovulation in a perimenopausal woman.4 6 The exact mechanism that leads from estrogen overexposure to endometrial hyperplasia is not fully understood. The endometrial estrogen receptor is involved as is demonstrated by the effect that tamoxifen, a selective estrogen receptor modulator (SERM), has on the endometrium. Tamoxifen and other SERMs are competitive inhibitors of estrogen for the estrogen receptor (ER). Depending on the site, tamoxifen binding to the ER can have either a stimulatory (pro-estrogenic) or inhibitory (anti-estrogenic) effect.7 In the uterus, as opposed to the breast, tamoxifen has a pro-estrogenic effect. Up to 40% to 50% of patients using tamoxifen will develop some form of endometrial hyperplasia or polyp.4 Further evidence of the link between unopposed estrogen and endometrial hyperplasia is the data from the PEPI trial, which showed that patients taking estrogen alone developed simple hyperplasia,

TABLE 1.11.1 Dimensions S, W, and h and Capacitance Scaling Factor K of Experimental lines Line 1 2 3 4 S 4.2 4.2 8.7 4.7 W 6.0 14.0 9.5 13.5 h 0.53 0.53 0.28 0.28 K 1.3 1.3 1.1 1.2

FIGURE 421 Use of spot and options to create a convertible priority in the event of a default, but typically it ranks above common stock The hybrid nature of preferred stock is supported by the fact that while some investment banks and investors warehouse these securities in their fixed income business, others manage them in their equity business One special type of preferred stock is known as a convertible As the name suggests, the security can be converted from a preferred stock product into something else at the choice of the investor The something else is usually shares of stock in the company that originally issued the preferred stock A convertible typically is structured such that it is convertible at any time, the conversion right is held by the investor in the convertible, and the convertible sells at a premium to the underlying security.

Investors accept the premium since convertibles tend to pay coupons that are much higher than the dividends of the underlying common stock Generally speaking, as the underlying common stock of a convertible declines, the convertible will trade more like a bond than an equity That is, the price of the convertible will be more sensitive to changes in interest rates than to changes in the price of the underlying common stock However, as the underlying stock price appreciates, the convertible will increasingly trade much more in-line with the price behavior of the underlying equity than with changes in interest rates Figure 422 shows a preferred stock s potential evolution from more of a bond product into more of an equity product A convertible s increasingly equitylike behavior is entirely consistent with the way a standard equity option would trade.

That is, as the option trades more and more in-the-money, the more its price behavior moves into lockstep with the price behavior of the underlying equity s forward or spot price Parenthetically, an option that can be exercised at any time is called an American option, while an option that can be exercised only at expiration is called a European option In the case of a European option type structure, if the underlying equity price is above the convertible-equity conversion price.

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